tissue plasminogen activator (tPA) | fibrinolytic and coagulative factors

“Low-amplitude vibration caused an increase in tPA
(tissue plasminogen activator, tPA)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274577/
Medical study from 2014-Oct-19

The study concludes, with one statement, “Whole body vibration training affects tPA and PAI-1 concentrations in healthy young men; and amplitude of vibrations seems an important variable in fibrinolytic factors.”

I don’t disagree with this generic conclusion. However there is very important data missing from the study:
— was the vibration source (WBV machine used in this study) extremely heavy? This is essential because the “amplitude” as measured without load will decreased in proportion to the user’s weight, if the weight of the vibrating device is not extremely heavy.  Almost certainly the vibration amplitude will be significantly reduced when loaded, compared to unloaded. Thus other important data:
— How much did each participant weight? Or, what is the measured loaded amplitude for each participant, and at each frequency? 4mm at 60Hz (as suggested in the study) will not be happening in reality. No person would tolerate this intensity.

 

A little info about tPA, relevant to those at high-risk of heart attack:

Tissue Plasminogen Activator (tPA)

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